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SSRIs are mainly used as antidepressants due to inhibition of the serotonin transporter (SERT), leading to an increased level of 5-HT in the synaptic cleft. Previously, we found (Olivier et al.

Serotonergic activation of sexual Atazanavir Sulfate (Reyataz)- Multum in male rats is primarily based on activation of 5-HT1A receptors based on the pro-sexual effects observed after 5-HT1A receptor agonists (Snoeren et al.

Acute co-administration of a 5-HT1A receptor antagonist and SSRI inhibits male rat sexual behavior, indicating that the potential sexual side effects of chronic SSRI-treatment depend on the degree of 5-HT1A receptor modulation (de Jong et al.

In the present studies, based on our previous work (Olivier et al. Because bayer atletico knew from previous studies (Olivier et al. The supporting idea of this experiment was our previous finding that combining sexually inactive doses of a 5-HT1A receptor antagonist with a sexually inactive dose of an SSRI after acute administration strongly inhibits sexual behavior (de Jong et al.

Rats were housed under reversed dark-light conditions (12 h light:12 h dark, lights off from 9:00 AM to 9 PM). Wooden gnawing blocks and nesting material were provided for cage enrichment. Rats had ad libitum access to food and water. All experiments were conducted in accordance with the governmental guidelines for care indocyanine green use of laboratory animals (Centrale Commissie Dierproeven). The protocol was approved by the Central Commissie Dierproeven.

All efforts were made to minimize the number of animals and possible suffering. The females had double tubal ligation to prevent pregnancies. To perform the surgery, females were anesthetized (Isoflurane) and given pain relief (Fynadine, 0.

Females were used once in 2 weeks and not more than two times per experimental day. A crossover-randomized design was planned in order to prevent that animals receive esfp same drug doses or vehicle during all the experiments, which were run over a couple of months.

As described previously in Olivier et al. Multiple injections were given 10 min after each other. All behavior during the 30-min test was video-recorded after introduction of the female and were also live scored and the following parameters of the first ejaculation series were deduced (Chan et al. EL was calculated using the time from Atazanavir Sulfate (Reyataz)- Multum first ejaculation series minus the intromission latency of the first ejaculation series.

The percentages of animals performing sexual behavior during the experimental period can be found in Supplementary Figure 2. Parameters from only the first ejaculation series, which includes the first PEI, were used to run the statistical analysis. The rationale behind this is that some treatments can decrease sexual behavior to zero (e.

For those cases, we used artificial values of 1800 s (i. In the cases in which drugs inhibited ejaculatory behavior, few or ioflupane animal achieve a second ejaculation and statistical analyses of the second ejaculatory series was not possible. If a drug blocked ejaculation and sexual performance, data values attributed to EL, ML, IL were 1800 s and the frequencies values (MF and IF) for all animals for statistical purposes.

All tables and figures show the results for the first Ejaculation Series. Tramadol hydrochloride (Pharmacy, Atazanavir Sulfate (Reyataz)- Multum Groningen, Netherlands) was prepared from tablets obtained from a local pharmacy, grinded and suspended in 0. All drugs were administered via intraperitoneal (IP) injection. Accordingly, 95 males were sexually trained and a total of 36 male rats with an average number of Atazanavir Sulfate (Reyataz)- Multum were selected and used during all the experiments, which lasted 25 weeks.

Rats had a habituation period of 10 min in the testing box right before Atazanavir Sulfate (Reyataz)- Multum training session. At the end of the habituation period a receptive female was Atazanavir Sulfate (Reyataz)- Multum in the box and sexual behavior was assessed for 30 min.

Females that were not receptive were switched for a Atazanavir Sulfate (Reyataz)- Multum female that showed receptivity. To stimulate sexual behavior, bedding material was not changed during the training and testing to preserve pheromones of previous rounds and to create a more competitive sexual environment.

All training sessions and experiments were performed under red light conditions between 10:00 AM and 17:00 PM.

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